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Unipro UGENE 64-bit is a free visual software solution for DNA and protein sequence analysis. UGENE provides customizable tools for visualization, analysis, annotation of genetic sequences.

Features:

Integrated tools
Multiple sequence alignment using MUSCLE 3, KAlign, Clustal;
HMM profiles build and search, based on the source of HMMER 2 and HMMER 3;
PCR Primers design using Primer 3;
Cloning in silico capabilities;
Queries to NCBI BLAST and CDD databases;
Protein secondary structure prediction using GOR IV and PSIPRED;
Phylogenetic analysis with Phylip;
Search for restriction enzymes and integration with REBASE;
Extremely fast repeat finder;
DNA short reads to reference alignment using Bowtie;
De novo assembly with CAP3;
Search for transcription factor binding sites using SITECON;
Protein back translation;
ORF finder;
Complete Smith-Waterman algorithm implementation;
Support for external tools: BLAST+, MAFFT, T-Coffee;
Assembly Browser — a shiny BAM viewer.

User interface
Visual and interactive genome browsing including circular plasmid view;
Multiple alignment editor;
Chromatograms visualization;
3D viewer for files in PDB and MMDB formats with anaglyph stereo mode support;
Phylogenetic tree viewer;
Dot plot visualization;
Query designer enables search for complex annotation patterns;
Easy to use workflow designer for custom computational workflows.

High performance computing in UGENE
Complete support of modern multicore processors and SSE instructions;
Out of the box support of modern GPUs using NVIDIA CUDA and ATI Stream;
Support for cloud computing: running computational tasks on Amazon EC2 cloud;
Support for supercomputers and distributed computing.

Cooperation
Can be used for education purposes in schools and universities;
Features to be included into the next release are initiated by users;
UGENE team is ready for collaboration in related projects, both free or commercial